01 - Whisk together buttermilk and hot sauce in a large bowl. Add chicken pieces, coating thoroughly. Cover and refrigerate for at least 4 hours or overnight for optimal flavor penetration.
02 - Combine flour, baking powder, baking soda, sugar, and salt in a large bowl. Cut in cold butter using a pastry cutter or fork until mixture resembles coarse crumbs. Add cold buttermilk and mix just until dough comes together. Turn onto a floured surface, gently pat to 3/4-inch thickness. Fold dough in half and pat out again; repeat twice for flakiness.
03 - Cut biscuits with a 2-inch cutter. Place on parchment-lined baking sheet, positioned close together for soft sides. Brush tops with buttermilk. Bake at 425°F for 12–15 minutes or until golden brown. Cool slightly before serving.
04 - Mix flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne in a shallow dish. Remove chicken from marinade, allowing excess to drip off. Dredge each piece in seasoned flour, pressing firmly to adhere coating. Let coated chicken rest for 10 minutes to set the breading.
05 - Heat 1–2 inches of vegetable oil in a large, heavy skillet to 350°F. Fry chicken in batches, turning occasionally, until golden brown and cooked through—approximately 15–18 minutes for dark meat, 12–15 minutes for white meat. Drain on wire rack or paper towels.
06 - Plate hot fried chicken alongside warm, flaky biscuits. Serve immediately while both components are at their peak temperature and texture.